Ryu Hyun-jin will start for the Los Angeles Dodgers in the second game of the season-opening series against the Arizona Diamondbacks in Sydney on March 23.
Two-time National League Cy Young Award winner Clayton Kershaw will start the first game, according to MLB.com.
This series is part of Major League Baseball's efforts to expand the sport's base around the world.
It also represents a clash between two bitter rivals in the West Division of the National League.
The Diamondbacks, who had to watch the Dodgers celebrate winning the division at their home stadium last season, hope to reach the postseason by beating the same foe this year. As such, the pressure on the two starting pitchers in the season-opening series could hardly be higher.