President Park Geun-hye started a state visit to Switzerland on Saturday night, a first for a South Korean head of state since the diplomatic relations were established in 1963.
Park will also attend the World Economic Forum in Davos from Tuesday to Wednesday.
Cheong Wa Dae economy chief Cho Won-dong said, "Despite a population of just eight million, Switzerland was ranked first in the world in national competitiveness by the WEF in 2013. There is a lot of room for cooperation in terms of the creative economy."
Meanwhile, Park on Saturday warned against taking recent overtures from North Korea at face value.
"We should focus on security against possible North Korean provocations especially when the North is making seemingly conciliatory gestures," she said.
Pyongyang last week called for an end to mutual denunciations and cancellation of joint South-Korea-U.S. military drills.